Hence, Lexus et al. engineered CAR-T cells to deliver immunostimulatory non-coding RNA RN7SL1 with EVs, which functions as a damage-associated molecular pattern (DAMP) to activate RNA PRRs in immune cells.1 Lexus et al. considered that CAR-T cells could kill target cancer cells within the scope of the EVs and thus realize selective tumor-infiltrated immune cells delivery, which avoids the initiation of cancer cell-intrinsic detrimental pathways. The gene discussed is RN7SL1; the disease is cancer.