Apart from age, risk of EM was also independently associated with WHO performance score 3–4 (HR, 3.68; 95% CI, 2.71–4.99), ≥60% bone marrow plasma cells (HR, 1.19; 95% CI, 1.00–1.41), thrombocytopenia (HR, 1.76; 95% CI, 1.37–2.26), serum β2-microglobulin ≥3.5 mg/L (HR, 1.59; 95% CI, 1.21–2.10), albumin <35 g/L (HR, 1.72; 95% CI, 1.45–2.02), hypercalcemia (HR, 1.69; 95% CI, 1.44–1.99), renal impairment (HR, 1.42; 95% CI, 1.21–1.67), anemia (HR, 1.17; 95% CI, 1.00–1.36), and high-risk cytogenetics (HR, 1.25; 95% CI, 1.00–1.57) (Table 2, multivariable model). This evidence concerns the gene HLA-G and Hypercalcemia.