CASP3 and neoplasm: Staining of these tumours with markers for cell proliferation (Ki67, Figs. 4F and S4C) and apoptosis (cleaved caspase-3, Figs. 4G and S4D), revealed that PF-477736 selectivity inhibits proliferation in LIMD1-deficient lung xenografts and increases apoptosis within these tumours, in agreement with our in vitro data.