LIMD1 and adenocarcinoma: These SAEC are a mixture of both type I and type II alveolar cells, thereby serving as an appropriate model of LUAD progenitor cells, which have been CRISPR-Cas9 edited to express a N-terminal truncated form of LIMD1 in significantly lower levels compared to non-targeting controls, thereby representing an in vitro model of LIMD1 loss in the development of adenocarcinoma (Fig. 4A).