The initial protocol was approved by East Midlands-Nottingham 2 Research Ethics Committee, (REC Ref: 20/EM/0115) on 5 May 2020, with subsequent amendments approved on 28 May 2020 (addition of namilumab and infliximab), 12 June 2020 (inclusion change-suspected COVID-19), 20 June 2020 (following dexamethasone as standard of care use), 12 October 2020 (change of primary outcome to CRP). This evidence concerns the gene CRP and COVID-19.