TNF and rheumatoid arthritis: For example, in RA, tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), and interleukin-1b (Il-1b) are three well-studied molecules for their role in joint inflammation and are the targets of biologic Disease Modifying Anti Rheumatic Drugs (bDMARDs) used in treatment [1, 2, 19].