Accordingly, ASB2 gene downregulation was toxic in four GCB DLBCL cell lines, bearing BCL2 translocation (OCI-Ly1, WSU-DLCL2) or concomitant BCL2/MYC translocation (VAL, DOHH2) (Fig. 4A and B). This evidence concerns the gene ASB2 and diffuse large B-cell lymphoma.