Indeed, over 60% of ABC-DLBCL and 30% of GCB DLBCL present nuclear localization of NFKB1/p50, compatible with an active classical NF-κB pathway, and/or of NFKB2/p52, as read out of an active alternative pathway [4]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.