Moreover, we took advantage of a genome-wide CRISPR-Cas9 screen of DLBCL cell lines [38] and identified a series of DLBCL driver genes that appeared as direct FLI1 targets, including ASB2 (ankyrin repeat-containing protein with a suppressor of cytokine signaling box 2). The gene discussed is EHMT2; the disease is diffuse large B-cell lymphoma.