In this type of sarcoma, the translocation t(11;22)(q24;q12) occurs between the central exons of FLI1 and the central exons of Ewing sarcoma breakpoint region1 (EWSR1) on chromosome 22, creating a fusion protein with dual transcriptional activator and repressor function [13–16]. Here, FLI1 is linked to Ewing sarcoma.