We profiled 22 human IDH-mutant grade II/III gliomas via snATAC-seq: 10 ATRX-mutant IDH-A and 12 ATRX wildtype, 1p/19q co-deleted IDH-O tumors (Fig. 1A, Additional file 1: Fig. S1A-C; Additional file 2: Table S1; Methods). This evidence concerns the gene ATRX and central nervous system cancer.