Likewise, in the scATAC-seq of murine IDH-mutant gliomas, we also observed significant enrichment for CTCF and CTCFL motifs in the peaks that were specific to ATRX-wildtype tumors, but we found no enrichment in ATRX-KO peaks (Fig. 4I, Additional file 7: Table S6). This evidence concerns the gene ATRX and central nervous system cancer.