Variables in the two groups were similar at baseline: body weight (p = 0.39), BMI (p = 0.09), neck circumference (p = 0.45), waist circumference (p = 0.07), abdominal circumference (p = 0.55), hip circumference (p = 0.40), body fat mass (p = 0.38), body lean mass (p = 0.66), insulin (p = 0.51), HOMA-IR (p = 0.35), HOMA-AD (p = 0.84), adiponectin (p = 0.31), leptin (p = 0.10), adiponectin/leptin (p = 0.23), ANP (p = 0.91) and FGF-21 (p = 0.74). This evidence concerns the gene LEP and Alzheimer disease.