In the present investigation, our aim was to analyse the effects of an interdisciplinary intervention on biomarkers of energy balance and inflammatory states such as leptin, adiponectin and ANP, according to the FGF21 response in women with overweight and obesity by dividing the sample into two groups after the intervention: those with increased FGF21 and those with decreased FGF21. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.