As targets, we utilized CEM.NKR CCR5+ Luc+ cells as these are 1) infectable with HIV (S9A Fig); 2) naturally resistant to NK killing without HIV infection; 3) express luciferase as a marker of HIV infection; and 4) can be desialylated by STSia to remove Siglec-9 ligands from their cell-surface (S9B Fig) which enhances NK activity against them (S9C Fig). We tested the ability of each of the three conjugates to potentiate the killing of HIV IIIB-infected cells by primary NK cells isolated from HIV-uninfected donors. Here, CCR5 is linked to HIV infectious disease.