Other candidates of note included Avp[7dpi↑] and Vip[7dpi↓] encoding vasoactive peptides, crucial for regulated SCN output following photic stimulation, the Pmch[7dpi↓] and Hcrt[7dpi↑] genes encoding the contrasting sleep-promoting melanin and wake-promoting orexin neuropeptides respectively and the African trypanosomiasis ID5143Thop1 gene [7dpi↑]. The gene discussed is VIP; the disease is human African trypanosomiasis.