CAV1 and neoplasm: An important clinical finding also reported elevated CAV-1 expression in 69 cases of brain metastasis from lung cancer (NSCLC), that instigated radioresistance and very poor outcome [42].Thus, TCGA clinical data clearly suggest that CAV-1 amplification is linked to copy number variation which is involved in altering downstream oncogenic signaling pathways that are aberrantly dysregulated in lung cancer, and responsible for radio-resistance and tumor aggression [43, 44].