ASGR1 and coronary artery disorder: Two loss-of-function variants in ASGR1 (12 bp deletion in the fourth intron that causes a frameshift mutation and a premature stop codon [carried by 1 in 120 persons], and a 4 bp insertion that introduces a stop codon at position 158 in the protein [carried by 1 in 1850 persons]) were identified in an Iceland population, and ASGR1 haploinsufficiency was associated with reduced levels of non-HDL-C and a reduced risk of coronary artery disease (CAD) [15].