PIK3CA and breast cancer: Data from either breast cancer cohort revealed a characteristic clustering pattern for PI3K signaling and stemness scores, including strong positive associations with proliferative (e.g., “G2M_checkpoint”, “E2F_targets”, “MYC_targets”) and metabolic (e.g., “Glycolysis”, “Oxidative_phosphorylation”, “Reactive_oxygen_species”) gene signatures (Figs 6 and 7).