Also, the overexpression of additional genes known to promote various mechanisms required for HR, including CtIP participating in ssDNA-end resection, PLK1 contributing to 53BP1 and RAD51 phosphorylation, and XRCC2, XRCC3, PALB2 participating in RAD51 filament assembly was reported in carcinoma cells with increased genomic instability. This evidence concerns the gene RBBP8 and carcinoma.