PALB2 and carcinoma: Also, the overexpression of additional genes known to promote various mechanisms required for HR, including CtIP participating in ssDNA-end resection, PLK1 contributing to 53BP1 and RAD51 phosphorylation, and XRCC2, XRCC3, PALB2 participating in RAD51 filament assembly was reported in carcinoma cells with increased genomic instability.