Interestingly, losing one copy of Ifnar1 was already sufficient to nearly abrogate the ability of BO‐110 to inhibit melanoma‐driven neolymphangiogenesis (see staining for Lyve1 and Prox1 in Fig 5E, and for more detail in Fig EV4C, and quantifications of this effect in Fig EV4D). This evidence concerns the gene LYVE1 and melanoma.