In this work, we have synthesized two family of ligands,an 8-oxoadenine derivative as a ligand for TLR7 and a pyrimido[5,4-b]indole as a ligand for TLR4, both conjugated with a T-cellpeptide of Pru p 3 allergen, the lipid transfer protein (LTP) responsiblefor LTP-dependent food allergy. This evidence concerns the gene TLR4 and food allergy.