It was previously reported that Ext.R administration could reverse left ventricular electrical remodeling and attenuate atrial fibrosis in rabbits with coronary ligation‐induced heart failure, possibly via ion channel regulation and activation of PI3K/AKT signaling.[35] In our study, we identified HBT, a less studied compound of Ext.R, as a key SGK1 inhibitor essential for the herb's cardiac protective function. Here, SGK1 is linked to heart failure.