Loss of SGK1 function shortened the lifespan in C. elegans by increasing mitochondrial permeability.[14] Inhibition of SGK1 suppressed oncogenic transformation.[15] SGK1 was also an important mediator of differentiation of the colorectal cells and inhibited colorectal cancer metastasis.[16] SGK1 was first implicated in the development of hypertrophy by Rosenzweig A et al. Here, SGK1 is linked to colorectal cancer.