OCLN and colitis: CD44 is a transmembrane glycoprotein, it is been observed that in many tumors and colitis tissues, an increased expression of CD44 has been observed where in HA binding and internalization are more significant, which plays a key role in HA internalization, degradation of ECM components, cell adhesion, proliferation, and migration.[34, 44, 45] Representative immunofluorescence images showing increased E‐cadherin, β‐catenin (epithelium), occludin (adherent junctional proteins) at the colitis epithelium with naïve HA and HA‐enema group compared to vehicle (PBS) control group (Figure 4E–H).