OCLN and colitis: We understand that the particles were uptaken by endocytosis and also due to the possibility of binding to surface receptors on the colitis inflammatory gut wall,[53] upon interaction of HA system, in downstream, there was an upregulation of transcription of genes that encode adherent epithelial/junctional proteins including E‐cadherin, β‐catenin, occludin, and inhibition of pro‐inflammatory cytokines.