The CKD RVOT exhibited higher expression levels of pCaMKII, ratios of pPLB S16 to PLB, pPLB T17 to PLB, pRyR S2808 to RyR and pRyR S2814 to RyR, and PKA relative to the control RVOT myocytes (Figure 6A). This evidence concerns the gene PLN and chronic kidney disease.