A potential explanation might be that reduced levels of lnc‐KCNQ1OT1 could exacerbate inflammation by regulating the XIAP axis and promoting multiple organ injury by targeting miRNAs (such as miR‐192‐5p and miR‐146a), while inflammation and multiple organ dysfunction often occur in sepsis.7, 14, 15. The gene discussed is KCNQ1OT1; the disease is Sepsis.