A recent study further extended the use of the macaque model in the evaluation of ADE and demonstrated increased levels of viremia, aspartate transaminase (AST), IL-10, IL-18, and IFN-γ and decreased levels of IL-12 in vaccinated macaques compared to non-vaccinated macaques, suggesting that vaccination may trigger ADE in DENV infection [12]. Here, IL18 is linked to acute disseminated encephalomyelitis.