To seek further genes relevant to multiple sclerosis, a differential expressionanalysis was performed between an extended cohort of CSF CD4+T-cells in 41 multiple sclerosis samples versus 38 NID control samples, whichidentified 140 significant genes at FDR <5% (Fig. 3 and Supplementary Table 16): 115 up-regulated and 25down-regulated. Here, CD4 is linked to multiple sclerosis.