CD4 and multiple sclerosis: In this study, we apply whole transcriptome sequencing tofluorescence-activated cell sorted CD4+ T-cells from the CSF andblood of large cohorts of multiple sclerosis patients and non-inflammatory disorder(NID) controls, identifying thousands of genes that are differentially expressedbetween CD4+ cells from CSF and blood, as well as genes that aredifferentially expressed in CSF CD4+ cells in multiplesclerosis.