Analysis of CSF CD4+ T-cells in anextended cohort of multiple sclerosis cases (totalN = 41) compared with non-inflammatorydisorder controls (total N = 38)identified 140 differentially expressed genes at false discovery rate <5%, many of which have known relevance to multiple sclerosis, includingXBP1, BHLHE40, CD40LG,DPP4 and ITGB1. Here, BHLHE40 is linked to multiple sclerosis.