The significant genes included many with plausible links withmultiple sclerosis pathogenesis, such as BHLHE40,56CD40LG,57DPP4 and ITGB1. The GO analysis identified 31enriched terms, which were all related to mitochondrial function, and there isgrowing evidence of mitochondrial dysfunction in multiple sclerosis.58 This evidence concerns the gene BHLHE40 and multiple sclerosis.