Interestingly, ThrbPV/PV mice deficient in SRC-3 (ThrbPV/PVSrc-3−/−) exhibit impeded thyroid cancer growth, progression and distant metastasis with a significantly increased survival, compared to ThrbPV/PV mice with normal SRC-3 function (ThrbPV/PVSrc-3+/+)[143]. The gene discussed is NCOA3; the disease is thyroid cancer.