KEAP1 and cancer: The Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response elements (Keap1-Nrf2-ARE) pathway is one of the most important defense mechanisms against oxidative stress [18] and is associated with a number of oxidative stress-related diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and aging [19].