In fact, the GPs in Italy should provide medical assistance to a great number of subjects, and the number of complex patients could be too heavy to be managed always in an optimal way; this crucial aspect can lead to the need to properly stratify CVr especially in the patients with diabetes, where atheromatosis, urinary albumin excretion, retinal disease, or worsening of renal function move the patients among the risk levels. The gene discussed is ALB; the disease is diabetes mellitus.