Similar to what we have reported here, a genetic variant near the gene encoding the matrix GLA protein (MGP) that also inhibits hydroxyapatite crystal growth has been tied to osteoporosis (25, 26) and is in linkage disequilibrium with a genetic variant in the MGP 5′-UTR tied to arterial calcification independent of atherosclerosis (51). Here, MGP is linked to osteoporosis.