LRRC1 can regulate downstream signaling through the C-terminal TSV sequence (Yamanaka and Ohno, 2008), the expression of which is higher in hepatocellular carcinoma tissues than in normal liver tissues, to promote tumor proliferation, invasion, and metastasis (Li et al., 2013; Hua et al., 2020). Here, LRRC1 is linked to hepatocellular carcinoma.