The PD-L1-negative patient (PD-L1 < 1%) also received immunotherapy and responded to nivolumab for 48 cycles that lasted 21.9 months, indicating a long-term tumor response of PD-1/PD-L1 inhibitors in patients irrespective of PD-L1 status (Brahmer et al., 2015). This evidence concerns the gene CD274 and neoplasm.