The early transcription of fmr1 gene and brain distribution of FMR1-mRNAs in human fetuses suggest that alterations of fmr1 gene expression in BFCS may be responsible for FXS typical executive and cognitive dysfunctions (Sarter et al., 2003; Hoeft 2010), and intellectual disability (Abitbol 1993). Here, FMR1 is linked to Intellectual disability.