Some of these oncogenic substrates, such as c-MYC, NOTCH 1, MCL-1, Cyclin E, and c-JUN, likely play a driver role in FBXW7-associated cancers (Fryer et al., 2004; Wei et al., 2005; Welcker and Clurman, 2008; Davis et al., 2014). This evidence concerns the gene FBXW7 and cancer.