Furthermore, SOX9 protein was also targeted by FBXW7 for proteasomal degradation in medulloblastoma cells even under normal unstressed conditions (Suryo Rahmanto et al., 2016), suggesting that FBXW7-mediated SOX9 degradation might be in a cell and context dependent event, and not specific to DDR. This evidence concerns the gene SOX9 and medulloblastoma.