TP53 and cancer: Given both FBXW7 and p53 are frequently mutated in many types of human cancers, we performed a bioinformatics analysis on TCGA databases and found interestingly that mutations of p53 and FBXW7 in human cancers are co-occurrence (Zehir et al., 2017), suggesting that this p53-FBXW7 negative feedback loop may have a biological implication.