TFAM and cancer: Among them, SCO1, HSPD1, IARS2, MRPL44, TFAM, NDUFS2, MRPL13, OPA1, and YARS have been previously identified as oncogenes in lung cancer or other types of cancers, serving as unfavorable prognosis biomarkers individually (Telang et al., 2012; Lee et al., 2017; Sotgia and Lisanti, 2017; Di et al., 2019; Dunham-Snary et al., 2019; Liu et al., 2019; Witherspoon et al., 2019; Li et al., 2020; Zhang et al., 2020; Cai et al., 2021).