Dysfunction in some specific members of mitochondrial genes, especially FH, SDH family, and IDH1/2, have been demonstrated as the milestone event for the development of multiple cancers like gliomas (Hartmann et al., 2009), glioblastomas (Balss et al., 2008), acute myeloid leukemia (Paschka et al., 2010), pheochromocytoma (Astuti et al., 2001), paraganglioma (Niemann and Müller, 2000; Astuti et al., 2001), and papillary renal cell cancer (Tomlinson et al., 2002; Luo et al., 2020). The gene discussed is SDHB; the disease is hereditary pheochromocytoma-paraganglioma.