SNORD116 and Prader-Willi syndrome: Besides, Snord116 deleted mouse model recapitulates major phenotypes of human PWS patients, including altered metabolism, growth deficiency, memory impairment, hyperphagia and increased anxiety (Skryabin et al., 2007; Ding et al., 2008; Zieba et al., 2015; Qi et al., 2016; Polex-Wolf et al., 2018; Adhikari et al., 2019).