Colorectal cancer (CRC) fueled by driver mutations in the Lgr5 + stem cells is accompanied by enrichment of CAF-derived TGF-β that suppresses the tumor-killing T cell populations, thus leading to greater metastases to the liver (Tauriello et al., 2018), highlighting the interplay between CAF, immune cells, and cancer cells. The gene discussed is TGFB1; the disease is colorectal cancer.