Whilst this is the first study examining TSPO expression after ionizing radiation exposure, several studies have demonstrated microglial activation after high dose ionizing radiation exposure (Hwang et al., 2006; Han et al., 2016; Lumniczky et al., 2017), often leading to cognitive decline (Acharya et al., 2016; Krukowski et al., 2018; Allen et al., 2020). This evidence concerns the gene TSPO and Mental deterioration.