Differential expression of genes (DEGs) in liver tissues of severe COVID-19 (GSE150316) and non-Covid 19 (GSE112356) patients have shown differential upregulation of host genes implicated in tissue remodeling (DNAJB1/hsp40, IGF2, EGFR, and HDGF), liver inflammation, and fibrosis such as metalloproteinases (MMP-3, 16,17, TIMP-1, 2, 4), collagens (COL6A3, 18A1-AS1, 20A1, 24A1, EC12, 13A1, 22A1, COLGALT2), and VCAM1. Here, DNAJB1 is linked to COVID-19.