LncRNA antisense noncoding RNA in the INK4 locus (ANRIL), initially identified in a kindred of familial melanoma-neural system tumor with a germ-line deletion of the entire CDKN2A/B locus in 2007, is located at the 9p21 region with 3.9 kb length and also named CDKN2B antisense RNA 1 (CDKN2B-AS) (211, 212). This evidence concerns the gene CDKN2B-AS1 and melanoma.