A total of 11 hub genes, four key miRNAs, and two key lncRNAs were found to be key factors in the ceRNA network, and the PVT1/miR-20b/CCND1 axis was identified as a promising pathway-related ceRNA axis in the progression of PC, which could be considered as encouraging a prognostic biomarker and therapeutic target for PC. The gene discussed is PVT1; the disease is pachyonychia congenita.