Similarity, another study showed that ROR could modulate the expression of polypyrimidine tract-binding protein 1/pyruvate kinase isozymes M2 (PTBP1/PKM2) through sponging miR-124 to induce PC cell autophagy, which led to gemcitabine resistance for PC (152). The gene discussed is PTBP1; the disease is pachyonychia congenita.