Mutations in KRAS and epidermal growth factor receptor (EGFR) can activate different signaling pathways including renin-angiotensin system/rapidly accelerated fibrosarcoma/Mitogen-activated protein kinase kinase/extracellular-signalregulated protein kinase (Ras/Raf/MEK/ERK) and phosphatidylinositol-3-kinase (PI3K)/Akt (13, 14). Here, EGFR is linked to fibrosarcoma.