Moreover, LINC01207 knockdown and miR-143-5p overexpression could inhibit PC cell proliferation, promote apoptosis, and induce autophagy by upregulating the expression of LC3II and beclin-1, while decreasing P62, AGR2, and the ratio of Bcl-2/Bax expression. This evidence concerns the gene AGR2 and pachyonychia congenita.