(243) demonstrated that DYNC2H1-4 acted as a sponge of miR-145 to upregulate the expression of its targets, MMP3, Oct4, Lin28, Nanog, Sox2, and ZEB1, thereby promoting EMT progression and CSC formation, which led to chemoresistance in PC cells. The gene discussed is POU5F1; the disease is pachyonychia congenita.