As displayed in Figure 2A, six pathways were significantly upregulated in ICC, namely DNA repair, E2F targets, G2M checkpoint, mitotic spindle, MYC targets V1, and TGF-β signaling; while seven pathways were dramatically downregulated, namely bile acid metabolism, cholesterol homeostasis, coagulation, fatty acid metabolism, pancreas beta cells, peroxisome, and xenobiotic metabolism. Here, MYC is linked to intrahepatic cholangiocarcinoma.