Recently, evidence suggests that CXCL1 secreted from tumor through the paracrine or autocrine mechanisms attracted various inflammatory cells (10, 21, 32, 42) or stromal cells (43, 44) into the tumoral microenvironment promoting tumor growth and metastasis, such as bladder (16), lung (17), and liver metastasis colorectal cancer (42). The gene discussed is CXCL1; the disease is colorectal cancer.