Inhibitors of FAK (FAKi), PI3K (LY294002 and wortmannin), Akt (Akti), and NF-κB (TPCK and PDTC) were applied and showed a clear suppression pattern of CXCL1-triggered cell migration and VCAM-1 mRNA expression in MG63 osteosarcoma cells (Figures 4A, B). Here, PTK2 is linked to osteosarcoma.