In ICC, Poliovirus receptor (PVR), as another immunosuppression-related molecule, was significantly lower in cluster 2 than in clusters 1 and 3 (Figure 4F), while the expression of TNF receptor superfamily member 14 (TNFRSF14) in cluster 2 was significantly higher than that in cluster 3 (Figure 4G). The gene discussed is TNFRSF14; the disease is intrahepatic cholangiocarcinoma.