CD4 and hepatocellular carcinoma: As shown in Figure 9B, infiltration levels of macrophage M0, T cell CD4+ Th1, and T cell CD4+ Th2 were significantly upregulated in the H2AFZhigh group, indicating that the H2AFZhigh group may have a lower Th1/Th2 ratio, which is an event related to tumor immune evasion and poor prognosis of HCC.