Many of the miRNAs and mRNAs have been previously found to play important roles in different types of cancer development, such as miR-544/RUNX3/NCR1/NKp46 axis in promoting hepatocellular carcinoma development (21), DNMT1 for aberrant DNA methylation (22), VEGFA for cancer-associated angiogenesis (23), among others. This evidence concerns the gene RUNX3 and hepatocellular carcinoma.