The univariate logistic regression analysis indicated that AFP > 200 μg/L (p = 0.000), maximum diameter >5 cm (p = 0.000), liver cirrhosis (p = 0.008), and GLDH > 7.45 U/L (p = 0.000) were risk factors for MVI in HCC. Here, AFP is linked to hepatocellular carcinoma.