We identified 15 differentially co-expressed core hub genes associated with the prognosis of DLBCL (RPS24, RPS21, RPL31, RPL30, RPS17, MRPS28, FAU, RPS25, RPL22L1, NDUFA6, CXCL9, CCL4, MRPL33, HEBP1, and RPL11). Here, RPS21 is linked to diffuse large B-cell lymphoma.