We identified 15 differentially co-expressed core hub genes associated with the prognosis of DLBCL (RPS24, RPS21, RPL31, RPL30, RPS17, MRPS28, FAU, RPS25, RPL22L1, NDUFA6, CXCL9, CCL4, MRPL33, HEBP1, and RPL11). Here, RPL30 is linked to diffuse large B-cell lymphoma.