Several studies have reported that AP significantly potentiates radiosensitization by promoting apoptosis and inducing cell cycle arrest at the G2/M phase by inhibiting the AKT and ERK pathways, including in cholangiocarcinoma and hepatocellular carcinoma (Huang et al., 2018; Yang & Qin, 2018). Here, AKT1 is linked to hepatocellular carcinoma.