S100A8 and dyspepsia: This CagA-independent inflammation could be supported by the low association between dyspepsia and CagA+ H. pylori strains observed in some worldwide patient cohorts (Andreolla et al., 2016; Bommelaer et al., 2001; Heikkinen et al., 1998; Nordenstedt et al., 2007; Vasiliou et al., 2014).