BCR and Familial prostate cancer: In this study, we used a combination of RNase R test, divergent primers, convergent primers, and Sanger sequencing to definitively demonstrate the circularization of exon #8 with exon #11 in the parent gene CSPP1. Survival analysis revealed that circCSPP1 might correlate with shorter BCR in patients with prostate cancer, even though the p value = 0.094.