HNRNPL and Familial prostate cancer: For example, our analysis based on four different publicly available datasets showed that circCSPP1 has higher expression in prostate cancer tissue than in benign tissue, or higher expression in high-grade prostate cancer tissue than in low-grade prostate cancer tissue, while an RNA immunoprecipitation (RIP) assay and mini-gene system data demonstrated that circCSPP1 was modulated by HnRNP-L (see Results).