As indicated in Figure 1, the increased expression of HnRNP-L likely upregulates the expression of circCSPP1; within tumor cells, circCSPP1 may sponge off miR-520h and thereafter unleash EGR1. As a result, the highly expressed EGR1 protein will upregulate autophagy-related gene expression at the transcriptional level, promoting tumor proliferation and metastasis. The gene discussed is HNRNPL; the disease is neoplasm.