The purpose of this study is to examine the association between adherence of LCD and sleep quality by the mediatory effect of inflammatory markers including high‐sensitivity C‐reactive protein (hs‐CRP), transforming growth factor‐β (TGF‐β), total antioxidant capacity (TAC) and interleukin‐1β (IL‐1β) in women with overweight and obesity. The gene discussed is TGFB1; the disease is obesity due to melanocortin 4 receptor deficiency.