Moreover, because the IFG secretion and binding were usually inhibited with the onset of excessive fat storage, the increased expression of Igfbp2 and the regulation of IGF binding function by 5% carrageenan suggested the relieving of obesity (Deodati et al., 2013; Yaylali et al., 2010). This evidence concerns the gene IGFBP2 and obesity due to melanocortin 4 receptor deficiency.