In addition, it was found that the expression of stearoyl‐CoA desaturase‐1 (Scd1) gene was significantly decreased (p < 0.05 & FC = 0.31) and colipase (Clps) increased (p < 0.05 & FC = 3.01) in the H5% group, indicating that 5% food‐grade κ‐carrageenan inhibited obesity through regulating fat synthesis and hydrolysis (Figure 4b). This evidence concerns the gene CLPS and obesity due to melanocortin 4 receptor deficiency.