TIMP1 and Hepatic fibrosis: Although the precise mechanisms of action of CJE and Cir were not demonstrated in this study, previous studies have revealed that natural products could prevent liver fibrosis by inhibiting tissue inhibitors of metalloproteinases‐1 (TIMP‐1) and transforming growth factor‐β (TGF‐β1) expression in mice (Choi et al., 2017; Periasamy et al., 2014).