To confirm this association between the 5HTTLPR heterozygous (LS) and homozygous (LL/SS) genotype with the BDNF dominant ancestral GG (Val/Val) genotype, 459 Chinese MDD participants were analyzed, and the combination of the LS (5HTTLPR) and GG (BDNF) genotypes increased three times the risk of developing MDD [37]. The gene discussed is BDNF; the disease is major depressive disorder.